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Real-time alerts associated with lower mortality

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A sophisticated system that analyzes electronic data about hospital patients, identifies those at risk of deteriorating, and issues an alert to a centralized team of specially trained nurses resulted in a lower mortality rate, Kaiser Permanente researchers found.

The evaluation of the Advance Alert Monitor, or AAM, used in 21 Kaiser Permanente Northern California hospitals, was published in the New England Journal of Medicine.

The study describes the results of a staggered deployment to Kaiser Permanente hospitals in Northern California between August 2016 and February 2019. The authors compared the outcomes for 15,487 patients who reached the alert threshold and 28,462 comparison patients who would have triggered an alert if the system had been active. The analysis found a 16% lower mortality rate among patients in the intervention cohort.

“Along with saving lives, the Advance Alert Monitor has demonstrated that it is possible to integrate predictive models into day-to-day operations in our medical centers,” said lead author Gabriel Escobar, MD, a research scientist with the Kaiser Permanente Division of Research and regional director for Kaiser Permanente Northern California operations research.

AAM predicts the probability that hospitalized patients are likely to decline, require transfer to the intensive care unit or emergency resuscitation, and benefit from interventions. Early warnings could be helpful for patients at risk of deterioration where may improve outcomes.

“Predictive analytics and machine learning are unlocking new frontiers in the use of complex patient data to improve our care in real time. They augment our clinicians’ practice by finding signals hidden within the electronic health record,” said coauthor Vincent Liu, MD, MS, a practicing intensivist and research scientist with the Division of Research, and regional director for Kaiser Permanente Northern California hospital advanced analytics.

The predictive model uses algorithms created from

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Frontotemporal Disorders: Hope Through Research


The Basics of Frontotemporal Disorders
Types of Frontotemporal Disorders
Common Symptoms
Treatment and Management
Caring for a Person with a Frontotemporal Disorder
Where can I get more information?


Few people have heard of frontotemporal disorders, which lead to dementias that affect personality, behavior, language, and movement. These disorders are little known outside the circles of researchers, clinicians, patients, and caregivers who study and live with them. Although frontotemporal disorders remain puzzling in many ways, researchers are finding new clues that will help them solve this medical mystery and better understand other common dementias.

The symptoms of frontotemporal disorders gradually rob people of basic abilities—thinking, talking, walking, and socializing—that most of us take for granted. They often strike people in the prime of life, when they are working and raising families. Families suffer, too, as they struggle to cope with the person’s daily needs as well as changes in relationships and responsibilities.

This booklet is meant to help people with frontotemporal disorders, their families, and caregivers learn more about these conditions and resources for coping. It explains what is known about the different types of disorders and how they are diagnosed. Most importantly, it describes how to treat and manage these difficult conditions, with practical advice for caregivers.


The Basics of Frontotemporal Disorders

Frontotemporal disorders are the result of damage to neurons (nerve cells) in parts of the brain called the frontal and temporal lobes. As neurons die in the frontal and temporal regions, these lobes atrophy, or shrink. Gradually, this damage causes difficulties in thinking and behaviors normally controlled by these parts of the brain. Many possible symptoms can result, including unusual behaviors, emotional problems, trouble communicating, difficulty with work, or difficulty with walking.

A Form of Dementia

Frontotemporal disorders are forms of dementia